The O&P PAC supports O&P friendly members of Congress serving on key committees that develop legislation affecting the O&P community. These are some of the political candidates, not an all-inclusive list, the O&P PAC has supported over the last few years:
- Rep. Jodey Arrington (R-TX)
- Rep. Gus Bilirakis (R-FL)
- Rep. Mike Bishop (R-MI)
- Rep. Michael Burgess (R-TX)
- Sen. Ben Cardin (D-MD)
- Sen. Tom Carper (D-DE)
- Sen. Bill Cassidy (R-LA)
- Rep. Gil Cisneros (D-CA)
- Sen. John Cornyn (R-TX)
- Sen. Steve Daines (R-MT)
- Rep. Ted Deutch (D-FL)
- Rep. Debbie Dingell (D-MI)
- Sen. Tammy Duckworth (D-IL)
- Rep. Renee Ellmers (R-NC)
- Rep. Anna Eshoo (D-CA)
- Rep. Brett Guthrie (R-KY)
- Sen. Charles Grassley (R-IA)
- Sen. Orrin Hatch (R-UT)
- Rep. French Hill (R-AK)
- Rep. Steve Horsford (D-NV)
- Rep. Robin Kelly (D-IL)
- Rep. James Lankford (R-OK)
- Rep. Daniel Maffei (D-NY)
- Rep. Kenny Marchant (R-TX)
- Rep. Brian Mast (R-FL)
- Sen. Clair McCaskill (D-MO)
- Rep. Michael McCaul (R-TX)
- Sen. Mitch McConnell (R-KY)
- Rep. Mark Meadows (R-NC)
- Rep. Jeff Miller (R-FL)
- Rep. Richard Neal (D-MA)
- Sen. Ben Nelson (D-NB)
- Rep. Frank Pallone (D-NJ)
- Rep. Erik Paulsen (R-MN)
- Rep. Tom Price (R-GA)
- Sen. Mark Pryor (D-AR)
- Rep. Hal Rogers (R-KY)
- Rep. Dutch Ruppersberger (D-MD)
- Sen. Brian Schatz (D-HI)
- Sen. Chuck Schumer (D-NY)
- Rep. Lamar Smith (R-TX)
- Sen. Debbie Stabenow (D-MI)
- Rep. Glenn Thompson (R-PA)
- Rep. Mike Thompson (D-CA)
- Rep. Lori Trahan (D-MA)
- Rep. Fred Upton (R-MI)
- Sen. Mark Warner (D-VA)
- Rep. Brad Wenstrup (R-OH)
- Sen. Ron Wyden (D-OR)